TWF, there is plenty of science, it is just that scientists don't always agree with each other. As Nuts and Speculator both suggested one of the main concerns with plastic bottles is BPA (bisphenol A). Hence some manufacturers advertising BPA free water bottles. There is also a lot of concern over DEHP.
DEHPPET (polyethylene terephthalate) bottles, which are commonly used in single use bottles for water, mineral-water and cordials, have been proven to leach DEHP (Bis(2-ethylhexyl)phthalate)
after repeated use. DEHP is a
probable carcinogen (
read the science here). Bis((2-ethylhexyl) phthalate is a synthetic colourless liquid with almost no odor. It is also known as Di(2-ehtylhexyl) phthalate or DEHP. It is commonly added to plastics to make them flexible. I am not sure that anyone has conclusively proven that DEHP does cause cancer in humans, but it has been linked to liver cancer in rats and mice, and testicular toxicity in rodens (particularly
young males).
In California, proposition 65 requires companies to list on labels any chemicals that are carcinogenic or reproductive hazards. This year DEHP was added to the list of chemicals that must be reported (
read more here) in California. In the USA, the EPA has classified DEHP as a Group B2,
probable human carcinogen. The United States National Toxicology Program (USNTP) concluded that DEHP is a reproductive and developmental toxicant in animals, the animal studies are relevant to humans. They concluded that current exposure levels are of concern for critically ill infants, healthy toddlers and babies during pregnancy and lactation. The EU have been working on DEHP toxicity since 1997, and has classified DEHP as a
health hazard and labeled it as "toxic". In 2005 the EU banned the use of DEHP in children's toys. Health Canada has been studying the question since 1994 and undertook
extensive studies in 2001 and reported that "not all species are equally susceptible to the toxic effects of DEHP. In particular, primates are thought to be less susceptible than rodents". However, in January 2002 they (HC) released strong recommendations against the use of DEHP in medical equipment. In 2002 the Japanese Health, Labour and Welfare ministry also recommended that PVC containing DEHP should not be used in medical devices.
But not everyone is convinced.
International Agency for Research on Cancer (IARC) reclassifies DEHP as Non-Carcinogenic to Humans.
Baxter Healthcare Corporation (Illinois-based maker of medical supplies) who manufacture a large percentage of IV bags used in the USA (which contain DEHP), took the matter to court in California and California Superior Court Judge Talmadge R. Jones ruled that Baxter had proven that the mechanism by which DEHP caused cancer in mice does not operate in humans. At the same time Baxter have announced the introduction of a line of intravenous products that don't contain DEHP.
The Vinyls Council of Australia concluded that there is "no substantiated evidence of harm to humans from exposures to phthalates (which include DEHP) despite decades of use. The benefits of some phthalate-plasticised PVC products such as medical devices are significant". They provide plenty of links on their site to argue their case.
You can read more about "End-of-life Environmental Issues with PVC in Australia" and in particular Phthalate Plasticizers on the
Department of Environment, Water, Heritage and Arts website.
BPAThe
Green Guide reports that "Depending on whom you talk to, BPA is either perfectly safe or a dangerous health risk. The plastics industry says it is harmless, but a growing number of scientists are concluding, from some animal tests, that exposure to BPA in the womb raises the risk of certain cancers, hampers fertility and could contribute to childhood behavioral problems such as hyperactivity".
There is a
Bisphenol A website which appears to be run by the American Chemistry Council (which represents the leading companies engaged in the business of chemistry, including significant business groups such as the Plastics Division and the Chlorine Chemistry Division). Their site has numerous links to articles confirming the safety of BPA including findings by the
European Food Safety Authority (EFSA) and the
US National Toxicology Program’s (NTP).
BPA mimics the hormone estrogen and Health Canada, concerned that infants up to 18 mths were being exposed to too much BPA, have (Oct 2008) listed it as a
Toxic substance and the Canadian Federal Goverment has moved to
ban baby bottles containing BPA and announced
a ban following a 60-day public comment period.
American ABC News reports a recent study linking BPA to
diabetes and heart disease in adults. This was also reported on
Medical News.Net.
Food Standards Australia and New Zealand "agrees with the risk assessment conducted by EFSA" (ie. estimated daily intakes of BPA are within safe limits). However they continue to monitor available information.
(
I was listening to the Cricket, so I had lots of Google time).